An H 2 S-Regulated Artificial Nanochannel Fabricated by a Supramolecular Coordination Strategy.

Hydrogen sulfide (H 2 S), as the third gasotransmitter, has an important impact on physiological and pathological activities. Herein, we fabricated an artificial nanochannel with a conductance value of 2.01 nS via a supramolecular coordination strategy. Benefiting from the unique H 2 S-mediated covalent reaction, the nanochannel biosensor could change from ON to OFF states with the addition of H 2 S. Furthermore, this nanochannel directed the ion transport, showing a high rectification ratio as well as gating ratio. Subsequently, theoretical simulations were conducted to help to reveal the possible mechanism of the functionalized nanochannel. This study can provide insights for better understanding the process of H 2 S-regulated biological channels and fabricating gas gated nanofluids.