Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock.

Pravin PatelNoor F ShaikYuhang ZhouKalyan GollaSteven E McKenzieUlhas P Naik

Published in: Journal of thrombosis and haemostasis : JTH (2020)

These findings suggest that ASK1 inhibition may be a potential target for the treatment of IC-induced shock and other immune-mediated thrombotic disorders.

Keyphrases

oxidative stress
pulmonary embolism
diabetic rats
high glucose
endoplasmic reticulum stress
cell cycle arrest
protein kinase
tyrosine kinase
combination therapy
smoking cessation