Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression.

Hoda Mojiri-Forushani Elham Khajehali Maryam Adelipour Zahra Nazeri

Published in: Molecular biology reports (2022)

The findings revealed that fluoxetine has anti-inflammatory properties, mainly due to the reduction of inflammatory cytokines and inhibition of JAK/STAT3 and TLR4/JNK gene expression in macrophages.

Keyphrases

gene expression
toll like receptor
inflammatory response
anti inflammatory
signaling pathway
dna methylation
immune response
cell death
induced apoptosis
oxidative stress
nuclear factor
single cell