Identification of autophagic target RAB13 with small-molecule inhibitor in low-grade glioma via integrated multi-omics approaches coupled with virtual screening of traditional Chinese medicine databases.

Wei SuMinru LiaoHuidan TanYanmei ChenRongyan ZhaoWenke JinShiou ZhuYiwen ZhangLi HeBo Liu

Published in: Cell proliferation (2021)

Our study identified the key autophagic regulators ZFP36L2 and Rab13 in LGG progression, and demonstrated that gallic acid is a small molecular inhibitor of RAB13, which negatively regulates autophagy and provides a possible small molecular medicine for the subsequent treatment of LGG.

Keyphrases

low grade
cell death
small molecule
high grade
oxidative stress
transcription factor
protein protein
single molecule
combination therapy
big data
artificial intelligence
smoking cessation