Abscopal effects of radiotherapy and combined mRNA-based immunotherapy in a syngeneic, OVA-expressing thymoma mouse model.

Lucas BaslerAleksandra KowalczykRegina HeidenreichMariola Fotin-MleczekSavas TsitsekidisDaniel ZipsFranziska EckertStephan M Huber

Published in: Cancer immunology, immunotherapy : CII (2018)

Combined irradiation and immunotherapy is able to induce abscopal responses, even with low, normofractionated radiation doses. Thus, the combination of mRNA-based vaccination with irradiation might be an effective regimen to induce systemic anti-tumor immunity.

Keyphrases

mouse model
radiation induced
early stage
radiation therapy
binding protein
locally advanced