Pre-eclampsia affects procalcitonin production in placental tissue.

Chiara AgostinisDamiano RamiPaola ZacchiFleur BossiTamara StampalijaAlessandro MangognaLeonardo AmadioRomana VidergarLiza Vecchi BrumattiGiuseppe RicciClaudio CeleghiniOriano RadilloIan SargentRoberta Bulla

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

Trophoblast cells are the main producer of PCT in PE placentae. TNF-α, in association with other circulating factors present in PE sera, upregulates PCT production in macrophages and normal placental cells, thus contributing to the observed increased in circulating PCT in PE sera.

Keyphrases

induced apoptosis
cell cycle arrest
rheumatoid arthritis
endoplasmic reticulum stress
signaling pathway
cell proliferation
pi k akt