Perfused boundary region as biomarker for endothelial integrity in former preterms in adolescence.
Liselotte Van LooKarel AllegaertLevtchenko ElenaZhen-Yu ZhangJan A StaessenAnke RaaijmakersPublished in: Pediatric research (2022)
The endothelial glycocalyx is a complex and versatile structure. Changes in blood pressure and retinal and renal vascularization suggest a disturbance of its integrity in extremely low birth weight (ELBW) survivors. Its thickness can be measured by calculating perfused boundary region (PBR) using sidestream dark-field imaging, with a higher PBR indicating a thinner glycocalyx. We generated reference values for PBR in healthy adolescents. These values were not different in former ELBW children. Despite some correlations of PBR with other microvascular biomarkers, these are not strong enough to describe endothelial integrity and its covariates in former ELBW children.
Keyphrases
- young adults
- low birth weight
- blood pressure
- endothelial cells
- preterm infants
- optical coherence tomography
- human milk
- preterm birth
- high resolution
- depressive symptoms
- diabetic retinopathy
- type diabetes
- hypertensive patients
- mass spectrometry
- blood glucose
- skeletal muscle
- photodynamic therapy
- weight loss
- glycemic control