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Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal.

Emma Michèle Harding-EschMartin J HollandJean-François SchémannAnsumana SillahBoubacar SarrLinus ChristersonHarry PickeringSandra Molina-GonzalezIsatou SarrAura A AndreasenDavid JeffriesChris GrundyDavid C W MabeyBjorn HerrmannRobin L Bailey
Published in: Parasites & vectors (2019)
We found that one round of MDA led to an overall decline in active trachoma prevalence but no impact on ocular C. trachomatis infection, with heterogeneity observed between villages studied. This could not be explained by MDA coverage or number of different circulating strains pre- and post-MDA. The poor correlation between active trachoma and infection prevalence supports the need for further work on alternative indicators to clinical signs for diagnosing ocular C. trachomatis infection. MLST typing has potential molecular epidemiology utility, including better understanding of transmission dynamics, although relationship to whole-genome sequence variability requires further exploration.
Keyphrases
  • risk factors
  • breast cancer cells
  • drug administration
  • escherichia coli
  • optic nerve
  • cell cycle arrest
  • healthcare
  • human health
  • optical coherence tomography
  • health insurance
  • affordable care act
  • light emitting