CSF concentration of cefotaxime in adult patients with pneumococcal meningitis: a multicentre retrospective study.

Paul Le TurnierNajoua El HelaliRomain GuilhaumouBenoit PilmisMatthieu RevestLionel J VellyAnne-Gaëlle LeroyXavier DuvalFlorian LemaitreMatthieu Gregoirenull null

Published in: The Journal of antimicrobial chemotherapy (2021)

Adult patients with pneumococcal meningitis treated with a high dose of cefotaxime (200 mg/kg/day) had elevated CSF concentrations with satisfying pharmacokinetics/pharmacodynamics parameters and tolerability profile. This study brings reassuring pharmacological data regarding the use of high-dose cefotaxime monotherapy for treating pneumococcal meningitis with susceptible strains to cefotaxime.

Keyphrases

high dose
cerebrospinal fluid
low dose
stem cell transplantation
open label
clinical trial
escherichia coli
double blind
study protocol
electronic health record
combination therapy
newly diagnosed
artificial intelligence
placebo controlled