Conferone, a coumarin from Ferula flabelliloba , induced toxic effects on adult T-cell leukemia/lymphoma cells.

Houshang RafatpanahMarziyeh GolizadehMaryam MahdifarShakiba MahdaviMehrdad IranshahiMohammad Reza Keramati

Published in: International journal of immunopathology and pharmacology (2023)

) in MT-2 cells. Accordingly, conferone could be considered as a potent agent against ATL, although complementary investigations are required to define more precisely its mechanism of action.

Keyphrases

induced apoptosis
cell cycle arrest
acute myeloid leukemia
signaling pathway
endoplasmic reticulum stress
bone marrow
cell death
high glucose
endothelial cells