Modeling methamphetamine use disorder and relapse in animals: short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain.
Khalid ElhadiAtul P DaiwileJean-Lud CadetPublished in: Neuroscience and biobehavioral reviews (2023)
Methamphetamine use disorder (MUD) is a neuropsychiatric disorder characterized by binge drug taking episodes, intervals of abstinence, and relapses to drug use even during treatment. MUD has been modeled in rodents and investigators are attempting to identify its molecular bases. Preclinical experiments have shown that different schedules of methamphetamine self-administration can cause diverse transcriptional changes in the dorsal striatum of Sprague-Dawley rats. In the present review, we present data on differentially expressed genes (DEGs) identified in the rat striatum following methamphetamine intake. These include genes involved in transcription regulation, potassium channel function, and neuroinflammation. We then use the striatal data to discuss the potential significance of the molecular changes induced by methamphetamine by reviewing concordant or discordant data from the literature. This review identified potential molecular targets for pharmacological interventions. Nevertheless, there is a need for more research on methamphetamine-induced transcriptional consequences in various brain regions. These data should provide a more detailed neuroanatomical map of methamphetamine-induced changes and should better inform therapeutic interventions against MUD.
Keyphrases
- electronic health record
- gene expression
- transcription factor
- big data
- high glucose
- systematic review
- diabetic rats
- physical activity
- dna methylation
- traumatic brain injury
- oxidative stress
- single molecule
- drug induced
- stem cells
- genome wide
- smoking cessation
- mesenchymal stem cells
- spinal cord injury
- neuropathic pain
- multiple sclerosis
- inflammatory response
- white matter
- climate change
- resting state
- artificial intelligence
- prefrontal cortex
- weight loss
- lipopolysaccharide induced
- risk assessment
- free survival