Improving thymus implantation for congenital athymia with interleukin-7.
Hyunjung MinLaura A ValenteLi XuShane M O'NeilLauren R BeggJoanne KurtzbergAnthony J FilianoPublished in: Clinical & translational immunology (2023)
athymic mice is an appropriate system to study thymus implantation for congenital athymia and immunodeficiencies. T cells are educated by the donor thymus, yet naïve T cells have deficits in expansion. IL-7 greatly improves T cell development after thymus implantation and may offer a novel strategy to improve outcomes of clinical thymus implantation.