Diabetes mellitus aggravates ranolazine-induced ECG changes in rats.

Habibeh Mashayekhi-Sardoo Amir Hooshang Mohammadpour Soghra Mehri Hossein Kamali Amir Hossein Sahebkar Mohsen Imenshahidi

Published in: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing (2021)

In summary, DM induction in animals resulted in CYP 3A2 inhibition and the prolongation of QT and QTc interval as well as bradycardia after ranolazine treatment.

Keyphrases

drug induced
high glucose
diabetic rats
heart rate variability
heart rate
glycemic control
skeletal muscle
adipose tissue
weight loss