Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study.
Marlou C BierlaaghPeter van MourikAnnelotte M VonkJohanna PottDanya MuilwijkGitte BerkersBente L AalbersFrank P VleggaarSabine MichelSylvia F BojRobert G J VriesJeffrey M BeekmanCornelis K van der Entnull nullPublished in: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2024)
Our results indicate that both rectal suction biopsy and forceps biopsy procedures are safe procedures. The high success rates of PDIO generation from the obtained tissue samples demonstrate the feasibility of the organoid technology for personalised in vitro testing in an international setting.