The genomic analysis unveils reduced genetic variability but an increased proportion of heterozygote genotypes of the intensively managed mezcal agave, Agave angustifolia Haw.

The considerable heterozygosity found in "espadín" is contained within a network of highly related individuals, displaying high linkage disequilibrium generated by decades of clonal propagation and possibly by the accumulation of somatic mutations. Wild A. angustifolia, on the other hand, represents a significant genetic diversity reservoir that should be carefully studied and conserved. This article is protected by copyright. All rights reserved.