MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats.

Yuji NakamachiKenichiro OhnumaKenichi UtoYoriko NoguchiJun SaegusaSeiji Kawano

Published in: Annals of the rheumatic diseases (2015)

We found that miR-124 ameliorated AIA by suppressing critical prerequisites for arthritis development, such as RANKL and NFATc1. Thus, miR-124a is a candidate for therapeutic use for human rheumatoid arthritis.

Keyphrases

rheumatoid arthritis
cell proliferation
long non coding rna
endothelial cells
long noncoding rna
disease activity
high glucose
early stage
ankylosing spondylitis
interstitial lung disease
diabetic rats
induced pluripotent stem cells
drug induced
nuclear factor
systemic sclerosis