A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients.
Gaia Chiara ManninoSerena PezzilliCarolina AvertaAnastasia FuocoRosangela SpigaElettra MancusoConcetta Di FattaFrancesco PerticoneSabrina PrudenteVincenzo TrischittaFrancesco AndreozziGiorgio SestiPublished in: Cardiovascular diabetology (2019)
We found that rs9267551 polymorphism is significantly associated with myocardial infarction in T2DM patients of European ancestry from two independent cohorts. It is possible that in subjects carrying the protective C allele less ADMA accumulates in endothelial cells causing vascular protection as a consequence of higher nitric oxide availability.
Keyphrases
- nitric oxide
- end stage renal disease
- endothelial cells
- heart failure
- left ventricular
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- genome wide
- gene expression
- type diabetes
- metabolic syndrome
- dna methylation
- adipose tissue
- vascular endothelial growth factor
- transcription factor
- glycemic control
- weight loss
- patient reported