Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: a case-controlled study (SIGNIFY).
Elizabeth K BancroftSibel SayaEmma BrownSarah ThomasNatalie TaylorJeanette RothwellJennifer PopeAnthony ChamberlainElizabeth PageSarah BenafifHelen HansonAlexander DiasChristos MikropoulosLouise IzattLucy SideLisa WalkerAlan DonaldsonJackie A CookJulian BarwellVicki WilesLauren LimbDiana M EcclesMartin O LeachSusan ShanleyFiona J GilbertDavid GallagherBalashanmugam RajashankerRichard W WhitehouseDow-Mu KohS Aslam SohaibDafydd Gareth EvansRosalind A EelesLeslie G WalkerPublished in: Journal of medical genetics (2019)
WB-MRI screening can be implemented in TP53 pv carriers without adverse psychosocial outcomes in the short and medium terms. A previous cancer diagnosis may predict a better psychosocial outcome. Some carriers seriously underestimate their risk of cancer. Carriers of pv should have access to a clinician to help them develop adaptive strategies to cope with cancer-related concerns and respond to clinically significant depression and/or anxiety.