Biocompatible Carbon-Based Coating as Potential Endovascular Material for Stent Surface.
Magdalena WawrzyńskaIwona Bil-LulaAnna Krzywonos-ZawadzkaJacek ArkowskiMikołaj ŁukaszewiczDariusz HreniakWiesław StrękGrzegorz SawickiMieczysław WoźniakMarek DrabKaja FrączkowskaMaciej DudaMarta KopaczyńskaHalina PodbielskaDariusz BiałyPublished in: BioMed research international (2018)
Stainless steel 316L is a material commonly used in cardiovascular medicine. Despite the various methods applied in stent production, the rates of in-stent restenosis and thrombosis remain high. In this study graphene was used to coat the surface of 316L substrate for enhanced bio- and hemocompatibility of the substrate. The presence of graphene layers applied to the substrate was investigated using cutting-edge imaging technology: energy-filtered low-voltage FE-SEM approach, scanning electron microscopy (SEM), Raman spectroscopy, and atomic force microscopy (AFM). The potential of G-316L surface to influence endothelial cells phenotype and endothelial-to-mesenchymal transition (EndoMT) has been determined. Our results show that the bio- and hemocompatible properties of graphene coatings along with known radial force of 316L make G-316L a promising candidate for intracoronary implants.
Keyphrases
- atomic force microscopy
- electron microscopy
- endothelial cells
- high speed
- raman spectroscopy
- single molecule
- high resolution
- room temperature
- carbon nanotubes
- stem cells
- walled carbon nanotubes
- human health
- pulmonary embolism
- bone marrow
- magnetic resonance imaging
- ionic liquid
- coronary artery disease
- mass spectrometry
- climate change
- magnetic resonance
- high glucose
- ultrasound guided
- photodynamic therapy
- soft tissue
- fluorescence imaging