A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons.

Sergio Espeso-GilTobias HaleneJaroslav BendlBibi KassimGabriella Ben HuttaMarina IskhakovaNeda ShokrianPavan AuluckBehnam JavidfarPrashanth RajarajanSandhya ChandrasekaranCyril J PeterAlanna CoteRebecca BirnbaumWill LiaoTyler BorrmanJennifer WisemanAaron BellMichael J BannonPanagiotis RoussosJohn F CraryZhiping WengStefano MarencoBarbara LipskaNadejda M TsankovaLaura HuckinsYan JiangSchahram Akbarian

Published in: Genome medicine (2020)

We uncovered shared nuclear topographies of cognitive and metabolic risk variants. More broadly, our PsychENCODE sponsored Hi-C study offers a novel genomic approach for the study of psychiatric and medical co-morbidities constrained by limited overlap of their respective genetic risk architectures on the linear genome.

Keyphrases

copy number
mental health
healthcare
genome wide
dna methylation
gene expression
functional connectivity
neural network