MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness.

Roser Farre GarrosRichard PaulMartin ConnollyAmy LewisBenjamin E GarfieldS Amanda NatanekSusannah BlochVincent MoulyMark J GriffithsMichael I PolkeyPaul R Kemp

Published in: American journal of respiratory and critical care medicine (2017)

Elevated miR-542-3p/5p may cause muscle atrophy in intensive care unit patients through the promotion of mitochondrial dysfunction and activation of SMAD2/3 phosphorylation.

Keyphrases

intensive care unit
end stage renal disease
epithelial mesenchymal transition
transforming growth factor
ejection fraction
newly diagnosed
mechanical ventilation
prognostic factors
peritoneal dialysis