Remission of hyperglycemia in spontaneously diabetic NOD mice upon transplant of microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS).
Pia MontanucciTeresa PescaraAlessia AlunnoOnelia BistoniGiuseppe BastaRiccardo CalafiorePublished in: Xenotransplantation (2018)
These data suggest that the stage of DM disease process in NOD mice, reflecting steady decline of residual b-cell mass, plays a pivotal role in determining the success of this cell therapy approach for treatment of DM.
Keyphrases
- umbilical cord
- cell therapy
- mesenchymal stem cells
- high fat diet induced
- endothelial cells
- stem cells
- bone marrow
- electronic health record
- metabolic syndrome
- insulin resistance
- big data
- innate immune
- combination therapy
- rheumatoid arthritis
- induced pluripotent stem cells
- machine learning
- wound healing
- glycemic control
- skeletal muscle
- weight loss