Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells.

S YousefniaD NaseriF Seyed ForootanM TabatabaeianF MoattarT GhafghaziM H Nasr EsfahaniKamran Ghaedi

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

Viola odorata extract exerted anti-cancerous activity on both breast cancer cell lines and their derived BCSCs. Anti-cancerous activity of this extract was significantly more in MCF7-, SKBR3-derived mammospheres in comparison with dedicated cell lines. Data suggest that Viola odorata extract mostly targets cancerous cells, not normal cells with exception in high concentration. It acts in a cell-dependent manner.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
cancer stem cells
anti inflammatory
endoplasmic reticulum stress
signaling pathway
cell death
cell therapy
big data
bone marrow
young adults
artificial intelligence