Lacunes, Microinfarcts, and Vascular Dysfunction in Cerebral Amyloid Angiopathy.
Elif GokcalMitchell J HornSusanne J van VeluwAina Frau-PascualAlvin S DasMarco PasiPanagiotis FotiadisAndrew D WarrenKristin SchwabJonathan RosandAnand ViswanathanJonathan R PolimeniSteven M GreenbergM Edip GurolPublished in: Neurology (2021)
Our findings show a high prevalence of lobar lacunes, frequently coexisting with CMIs in CAA, suggesting that these 2 lesion types may be part of a common spectrum of CAA-related infarcts. Lacunes were not related to vascular dysfunction but predicted incident ICH, favoring severe focal vessel involvement rather than global ischemia as their mechanism.