Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation.

Hongying LiYuqin YuanHong DongTinghui WangDunlan ZhangLimin ZhouLu ChenXueyan He

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2023)

This research underlines that Foxo3a blocks its methylation with the PTEN promoter by inhibiting DNMT3B activity, which subsequently impedes cervical cancer cell progression.

Keyphrases

dna methylation
pi k akt
signaling pathway
genome wide
gene expression
transcription factor
cell proliferation