Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains.
Lorena BernardoAna Victoria Ibarra-MenesesNoelie DouanneAudrey CorbeilJose Carlos SolanaFrancis BeaudryEugenia CarrilloJavier MorenoChristopher Fernandez-PradaPublished in: PLoS neglected tropical diseases (2024)
Our results show the potential selection of Sb-MTX cross-resistant parasites in the field, pointing to the possibility to undermine antileishmanial treatment of those patients being treated with immunosuppressant drugs in Leishmania endemic areas.