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Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains.

Lorena BernardoAna Victoria Ibarra-MenesesNoelie DouanneAudrey CorbeilJose Carlos SolanaFrancis BeaudryEugenia CarrilloJavier MorenoChristopher Fernandez-Prada
Published in: PLoS neglected tropical diseases (2024)
Our results show the potential selection of Sb-MTX cross-resistant parasites in the field, pointing to the possibility to undermine antileishmanial treatment of those patients being treated with immunosuppressant drugs in Leishmania endemic areas.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • escherichia coli
  • peritoneal dialysis
  • low dose
  • combination therapy
  • plasmodium falciparum
  • patient reported