Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains.

Lorena BernardoAna Victoria Ibarra-MenesesNoelie DouanneAudrey CorbeilJose Carlos SolanaFrancis BeaudryEugenia CarrilloJavier MorenoChristopher Fernandez-Prada

Published in: PLoS neglected tropical diseases (2024)

Our results show the potential selection of Sb-MTX cross-resistant parasites in the field, pointing to the possibility to undermine antileishmanial treatment of those patients being treated with immunosuppressant drugs in Leishmania endemic areas.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
escherichia coli
peritoneal dialysis
low dose
combination therapy
plasmodium falciparum
patient reported