Virome Analysis and Association of Positive Coxsackievirus B Serology during Pregnancy with Congenital Heart Disease.
Mathieu GarandSusie S Y HuangLisa S GoesslingFei WanDonna A SantillanMark K SantillanAnoop BrarTodd N WylieKristine M WyliePirooz EghtesadyPublished in: Microorganisms (2023)
Detection of viral nucleic acid in plasma was infrequent and specifically no CVB genome was detected. However, serology demonstrated that prior CVB exposure is higher in CHD-affected pregnancies. Further studies are warranted to understand the magnitude of the contribution of the maternal blood virome to the pathogenesis of CHD.