microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia.

Ling XuYu FuWeiwen ZhuRongyao XuJuan ZhangPing ZhangJie ChengHongbing Jiang

Published in: Journal of cellular biochemistry (2018)

Our results show the functional deficiencies of BMSCs-CCD and a potential role of miR-31 in BMSCs-CCD deficiencies. The application of miR-31 inhibitor in BMSCs-CCD might lend hope for developing BMSC-based therapeutic approaches against CCD-associated skeletal diseases.

Keyphrases

cell proliferation
bone marrow
long non coding rna
long noncoding rna
mesenchymal stem cells
risk assessment
human health
replacement therapy