Fatal Chemotherapy-induced Combined Infection in a Hodgkin’s Disease Patient: a Case Report.
Yordan I KalchevGergana B LengerovaUswah AsifHasan A BurnusuzovMarianna A MurdjevaPublished in: Folia medica (2020)
Multimodal therapy, used for the treatment of patients with Hodgkin’s disease (HD), makes them prone to life-threatening infections, attributed mainly to febrile neutropenia. Herein, we present a case report of fatal combined bacterial and viral infection in a 49-year-old female patient, subject to polychemotherapy for HD. Rapid microbiological diagnosis performed by multiplex polymerase chain reaction elucidated the causes of the infection within hours. Listeria monocytogenes was detected in both the cerebrospinal fluid and blood samples. Nasopharyngeal swabs returned positive for two swine-derived strains of influenza A virus. We aimed to emphasize the importance of these pathogens and draw attention to their association in the aetiology of infections among patients receiving chemotherapy. In conclusion, better surveillance is needed to improve the early diagnosis of infectious complications in these patients.
Keyphrases
- chemotherapy induced
- listeria monocytogenes
- cerebrospinal fluid
- end stage renal disease
- case report
- ejection fraction
- newly diagnosed
- public health
- escherichia coli
- chronic kidney disease
- hodgkin lymphoma
- working memory
- squamous cell carcinoma
- stem cells
- prognostic factors
- patient reported outcomes
- radiation therapy
- bone marrow
- combination therapy
- cell therapy
- patient reported
- chronic pain
- smoking cessation
- antimicrobial resistance