Salience Network Segregation Mediates the Effect of Tau Pathology on Mild Behavioral Impairment.

Alexandru D IordanRobert Ploutz-SnyderBidisha GhoshAnnalise Rahman-FilipiakRobert KoeppeScott PeltierBruno GiordaniRoger L AlbinBenjamin M Hampstead

Published in: medRxiv : the preprint server for health sciences (2024)

Our findings suggest an indirect role of tau pathology in MBI through brain network dysfunction and emphasize the role of the salience network in mediating relationships between neuropathological changes and behavioral manifestations.

Keyphrases

functional connectivity
resting state
cerebrospinal fluid
white matter