Detection of Isotopic Atropisomerism Based on ortho-H/D Discrimination.

Kazuya SaitoShota MiwaAsumi IidaYuuki FujimotoElsa CaytanChristian RousselOsamu Kitagawa

Published in: Organic letters (2021)

Racemic and optically active 3-(2-deuteriophenyl)-2-(1-phenylpropan-2-yl)quinazoline-4-thiones were prepared. The nuclear magnetic resonance spectra clearly show that they exist as a 1:1 mixture of diastereomers due to the isotopic atropisomerism based on ortho-H/D discrimination (N-C axial chirality) and a chiral carbon.

Keyphrases

magnetic resonance
loop mediated isothermal amplification
real time pcr
contrast enhanced
density functional theory
ionic liquid
capillary electrophoresis
mass spectrometry