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The effect of gastrointestinal graft-versus-host disease and diarrhea on the pharmacokinetic profile of sotrovimab in hematopoietic stem cell transplant recipients.

Jim BoonyaratanakornkitQianwen WangAhmed NaderLouise KimballTerry Stevens-AyersMarta LevkovaRachel BlazevicJeanette NguyenJennifer WrightJared CastorAlexander L GreningerEmily FordMarco MielcarekShelley FordredJennifer HanMichael BoeckhAlpana Waghmare
Published in: The Journal of infectious diseases (2024)
These data show that sotrovimab exposure may be reduced in HCT recipients, possibly related to increased GI clearance in patients with GVHD. This phenomenon has implications for dose selection and duration of efficacy with sotrovimab and potentially other mAbs in this vulnerable patient population. Thus, mAb dose regimens developed in non-HCT populations may have to be optimized when applied to HCT populations.
Keyphrases
  • hematopoietic stem cell
  • cell cycle arrest
  • case report
  • genetic diversity
  • electronic health record
  • pi k akt
  • data analysis