Cancer risks among first-degree relatives of women with a genetic predisposition to breast cancer.

Qingyang Xiao Xinhe Mao Alexander Ploner Felix GrassmannJuan RodriguezMikael ErikssonPer Hall Kamila Czene

Published in: Journal of the National Cancer Institute (2024)

Protein-truncating variants of risk genes and higher polygenic risk score in index women are associated with an increased risk of breast and other hereditary breast and ovary syndrome-related cancers among relatives.

Keyphrases

genome wide
copy number
papillary thyroid
breast cancer risk
polycystic ovary syndrome
childhood cancer
squamous cell
case report
protein protein
human health
gene expression
squamous cell carcinoma
metabolic syndrome
amino acid
lymph node metastasis
adipose tissue
small molecule
bioinformatics analysis