The expanding morphological and genetic spectrum of MYOD1-mutant spindle cell/sclerosing rhabdomyosarcomas: a clinicopathological and molecular comparison of mutated and non-mutated cases.

Jen-Wei TsaiYi-Che ChangChienJen-Chieh LeeYu-Chien KaoWan-Shan LiCher-Wei LiangI-Chuang LiaoYi-Ming ChangJui-Chu WangCheng-Feng TsaoShih-Chen YuHsuan-Ying Huang

Published in: Histopathology (2019)

MYOD1-mutant RMSs are uncommonly mutated with PIK3CA and behave aggressively with an expanded morphological and genetic spectrum, including lipoblastic differentiation, multinucleated cells and the alternative p.E118K mutation.

Keyphrases

wild type
induced apoptosis
genome wide
cell cycle arrest
single cell
copy number
cell therapy
endoplasmic reticulum stress
gene expression
oxidative stress
dna methylation
cell death
stem cells
signaling pathway
bone marrow
clinical evaluation