Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.

Álvaro Cobo-CalvoAnne RuizChloé RichardSandrine BlondelSylvie CavagnaNathalie StrazielleJean-François Ghersi-EgeaPascale GiraudonRomain Marignier

Published in: PloS one (2020)

Human NMO-IgG induces both structural and functional alterations of BBB properties, suggesting a direct role of NMO-IgG on modulation of BBB permeability in NMOSD.

Keyphrases

blood brain barrier
endothelial cells
end stage renal disease
spectrum disorder
cerebral ischemia
chronic kidney disease
ejection fraction
prognostic factors
induced pluripotent stem cells
patient reported