Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study.
Ehsan BahramaliMona RajabiJavad JamshidiSeyyed Mohammad MousaviMehrdad ZarghamiAlireza ManafiNegar FirouzabadiPublished in: BMJ open (2016)
In patients with hypertension who develop HFpEF, the D allele of the ACE gene is probably associated with the development of LVH. With the detrimental effects of LVH on the heart's diastolic properties, this can signify the role of genetic contributors to the development of HFpEF in patients with hypertension and may serve as a future risk predictor for the disease.
Keyphrases
- left ventricular
- heart failure
- blood pressure
- genome wide
- copy number
- cardiac resynchronization therapy
- hypertrophic cardiomyopathy
- acute myocardial infarction
- mitral valve
- angiotensin converting enzyme
- aortic stenosis
- left atrial
- angiotensin ii
- ejection fraction
- acute heart failure
- genome wide identification
- dna methylation
- aortic valve
- transcatheter aortic valve replacement