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Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies.

Armin GhobadiJack H LandmannAlun CarterMatthew L CooperMehmet Emrah SelliJufang ChangMatthew L BakerChristopher A MillerFrancesca FerraroDavid Y ChenAmanda M SmithTaylor A LaValleEric J DuncavageJustin ChouVictor TamJoseph M BenounJenny NaterNathalie SchollerFrancesca MillettiRemus VezanAdrian BotJohn M RossiNathan Singh
Published in: Blood advances (2022)
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • small molecule
  • acute myeloid leukemia
  • cancer therapy
  • high throughput
  • copy number
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • gene expression
  • dna methylation