Impact of Cytoreductive Nephrectomy in the Management of Metastatic Renal Cell Carcinoma: A Multicenter Retrospective Study.
Naotaka KumadaKoji IinumaYasuaki KubotaKimiaki TakagiMasahiro NakanoTakashi IshidaShigeaki YokoiFumiya SuginoMakoto KawaseShinichi TakeuchiKota KawaseDaiki KatoManabu TakaiYuki TobisawaTakayasu ItoKeita NakaneTakuya KoiePublished in: Diseases (Basel, Switzerland) (2024)
In this study, we aimed to determine the utility of cytoreductive nephrectomy (CN) in real-world clinical practice and investigate whether CN contributes to improved oncological outcomes in patients with metastatic renal cell carcinoma (mRCC). This retrospective multicenter cohort study enrolled patients with mRCC who received systemic therapy at six institutions between May 2005 and May 2023. The patients were divided into those who did not undergo CN (Group I) and those who underwent CN (Group II). The primary endpoints were oncological outcomes, including cancer-specific survival (CSS) and progression-free survival (PFS). Altogether, 137 patients with mRCC were included in this study. The median CSS was 14 months in Group I and 32 months in Group II ( p < 0.001). Additionally, the median PFS in Groups I and II was 5 and 13 months, respectively ( p = 0.006). A multivariate analysis showed that CN was an independent prognostic factor for CSS and PFS. Hence, CN is a potential treatment modality that can improve oncological outcomes in patients with mRCC.
Keyphrases
- metastatic renal cell carcinoma
- lymph node metastasis
- prognostic factors
- robot assisted
- free survival
- papillary thyroid
- clinical practice
- rectal cancer
- end stage renal disease
- radical prostatectomy
- prostate cancer
- squamous cell carcinoma
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- peritoneal dialysis
- clinical trial
- adipose tissue
- mesenchymal stem cells
- risk assessment
- glycemic control
- double blind
- weight loss
- replacement therapy
- patient reported
- drug induced