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HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.

Xue-Zhong CaoMeng-Ye ZhuGang XuFan LiYi YanJin-Jin ZhangJianbing WangFei ZengYang BaoXue-Xue ZhangTao LiuDa-Ying Zhang
Published in: CNS neuroscience & therapeutics (2024)
Our results indicated that the LHb neurons were hyperactive under CADS in chronic pain, and this hyperactivation possibly resulted from the enhanced function of HCN channels and up-regulation of HCN2 isoforms.
Keyphrases
  • chronic pain
  • pain management
  • spinal cord
  • bipolar disorder
  • high fat diet induced
  • stress induced
  • type diabetes
  • neuropathic pain
  • spinal cord injury
  • metabolic syndrome
  • insulin resistance
  • skeletal muscle