Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-κB/NFATc-1.

L Wilches-BuitragoP R ViacavaF Q CunhaJ C Alves-FilhoSandra Yasuyo Fukada Alves

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

Altogether these data show a protective role of a natural glycolytic intermediate in bone homeostasis that may have therapeutic benefit for osteolytic diseases.

Keyphrases

bone loss
lps induced
nuclear factor
high glucose
signaling pathway
diabetic rats
electronic health record
oxidative stress
bone mineral density
pi k akt
soft tissue
endothelial cells
body composition
cell proliferation
stress induced