Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment.
Jihye LeeJusung LeeGeum Jin KimInho YangWeihong WangJoo-Won NamHyukjae ChoiSang-Jip NamHeonjoong KangPublished in: Marine drugs (2019)
Mycousfurans (1 and 2), two new usnic acid congeners, along with (-)-mycousnine (3), (-)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus.
Keyphrases
- high performance liquid chromatography
- staphylococcus aureus
- high resolution
- simultaneous determination
- mass spectrometry
- tandem mass spectrometry
- heavy metals
- solid phase extraction
- density functional theory
- ms ms
- magnetic resonance
- pseudomonas aeruginosa
- escherichia coli
- polycyclic aromatic hydrocarbons
- risk assessment
- high intensity
- anti inflammatory
- cystic fibrosis
- liquid chromatography
- biofilm formation