Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis.
Charalambos GogosEvangelos J Giamarellos-BourboulisDimitrios VelissarisTheologia GkavogianniCharalambos GogosPublished in: Infectious diseases (London, England) (2021)
Sepsis evolution and outcome are influenced by multiple factors. Although MDR pathogens induced a weaker immune response characterized by lower TNF-α levels this was not accompanied by better survival. Increased Ang-2 levels, APACHE II score and carbapenem resistance are important factors associated with higher mortality.
Keyphrases
- gram negative
- multidrug resistant
- acinetobacter baumannii
- drug resistant
- klebsiella pneumoniae
- immune response
- acute kidney injury
- septic shock
- intensive care unit
- rheumatoid arthritis
- high glucose
- angiotensin ii
- cardiovascular events
- cardiovascular disease
- diabetic rats
- type diabetes
- cystic fibrosis
- oxidative stress
- pseudomonas aeruginosa
- free survival
- inflammatory response