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Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress.

Devon L MooseMichael D Henry
Published in: Molecular & cellular oncology (2020)
During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues. We have recently shown that cancer cells from diverse tissues actively resist destruction by fluid shear stress through a mechano-adaptive RhoA-actomyosin mechanism.
Keyphrases
  • circulating tumor cells
  • circulating tumor
  • gene expression
  • papillary thyroid
  • squamous cell
  • lymph node
  • cell free
  • free survival
  • squamous cell carcinoma
  • lymph node metastasis
  • young adults