PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1.

Kwan Long MungWilliam B EccleshallNiina M SantioAdolfo Rivero-MüllerPäivi J Koskinen

Published in: Cell communication and signaling : CCS (2021)

PIM kinases are novel negative regulators of LKB1 that affect AMPK activity in an LKB1-dependent fashion. The impairment of cell proliferation and tumor growth in cells lacking both LKB1 and PIMs indicates that these kinases possess a shared signaling role in the context of cancer. These data also suggest that PIM inhibitors may be a rational therapeutic option for LKB1-deficient tumors. Video Abstract.

Keyphrases

cell proliferation
skeletal muscle
induced apoptosis
papillary thyroid
squamous cell carcinoma
cell cycle arrest
transcription factor
machine learning
cell cycle
young adults
oxidative stress
wild type