Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases.
Robert D MorganGeorge J BurghelNicola FlaumMichael BulmanAndrew R ClampJurjees HasanClaire L MitchellHelene SchlechtEmma R WoodwardFiona I LalloEmma J CrosbieRichard J EdmondsonAndrew J WallaceGordon C JaysonDafydd Gareth EvansPublished in: Journal of medical genetics (2019)
Our study suggests that age at diagnosis, family history of breast and/or ovarian cancer, medical history of breast cancer or a Manchester BRCA Score of ≥15 points are associated with a >10% prevalence of germline pathogenic BRCA1/2 variants in epithelial ovarian cancer.