Genome-wide association meta-analysis of functional outcome after ischemic stroke.

Martin SöderholmAnnie PedersenErik LorentzenTara M StanneSteve BevanMaja OlssonJohn W ColeIsrael Fernandez-CadenasGraeme J HankeyJordi Jimenez-CondeKatarina JoodJin-Moo LeeRobin LemmensChristopher R LeviBraxton D MitchellBo NorrvingKristiina RannikmäeNatalia S RostJonathan RosandPeter M RothwellRodney ScottDaniel StrbianJonathan W SturmCathie SudlowMatthew TraylorVincent N ThijsTurgut TatlisumakDaniel WooBradford B WorrallJane M MaguireArne LindgrenChristina Jernnull null

Published in: Neurology (2019)

In this large GWA study on functional outcome after ischemic stroke, we report one significant variant and several variants with suggestive association to outcome 3 months after stroke onset with plausible mechanistic links to poststroke recovery. Future replication studies and exploration of potential functional mechanisms for identified genetic variants are warranted.

Keyphrases

genome wide association
systematic review
case control
atrial fibrillation
copy number
current status
risk assessment
upper limb