A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis.

Philipp KönigRoman ZhulenkoEloy SuparmanHenrik HoffmeisterNico BückreißIngo OttGerd Bendas

Published in: Cancer chemotherapy and pharmacology (2023)

These data reflect the complexity of cisplatin resistance in cell models and emphasize NHC-Au(I)-complexes as prospective cytotoxic agents for further investigations in that respect.

Keyphrases

endoplasmic reticulum stress
oxidative stress
single cell
electronic health record
cell therapy
cell cycle arrest
cell death
transcription factor
big data
bone marrow
mesenchymal stem cells
endoplasmic reticulum
silver nanoparticles
quantum dots