Breaking bad.

Mohini Bhattacharya Alexander R Horswill

Published in: The Journal of experimental medicine (2023)

DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221086) develop D1-/-, D1L3-/-, and D1-/-D1L3-/- mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms.

Keyphrases

staphylococcus aureus
drug delivery
candida albicans
biofilm formation
methicillin resistant staphylococcus aureus
wild type
pseudomonas aeruginosa
drug induced