Exome Sequencing of 21 Bardet-Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians.

Samantha E Day Yunhua L Muller Çiğdem KöroğluSayuko KobesKim WiedrichDarin MahkeeHye In KimCris Van HoutNehal GosaliaBin Yenull nullAlan R ShuldinerWilliam C KnowlerRobert L HansonClifton BogardusLeslie J Baier

Published in: Obesity (Silver Spring, Md.) (2021)

Potentially functional variants in BBS genes in American Indians are reported. However, functional evidence supporting a causal role for BBS9 in obesity is inconclusive.

Keyphrases

copy number
insulin resistance
genome wide
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
genome wide identification
bioinformatics analysis
dna methylation
case report
skeletal muscle
body mass index
transcription factor