Resolution of Large Choroidal Tuberculoma following Monotherapy with Intravitreal Ranibizumab.
Sahil JainAniruddha Kishandutt AgarwalVishali GuptaPublished in: Ocular immunology and inflammation (2019)
Background: Ocular tuberculosis can have protean manifestations. Anti-tubercular therapy (ATT) and oral steroids are employed in the management of this condition. There is evidence in the literature which has highlighted the use of intravitreal anti-vascular endothelial growth factor drugs as an adjunct to systemic therapy.Report of the Case: A 44-year-old male presented with a decrease of vision in the right eye was diagnosed choroidal tuberculoma with massive exudation and subretinal fluid. The patient was treated with intravitreal ranibizumab injection. The lesion regressed completely within 6 weeks without any additional systemic corticosteroids and ATT without any recurrence over 6 months during follow-up.Conclusions: Ranibizumab monotherapy may lead in complete regression of vascularized tubercular choroidal granulomas without the need of adjunctive ATT and corticosteroids. After intravitreal injection of ranibizumab, the lesion may be observed for regression over several weeks.
Keyphrases
- age related macular degeneration
- vascular endothelial growth factor
- diabetic retinopathy
- optical coherence tomography
- systematic review
- combination therapy
- endothelial cells
- ultrasound guided
- open label
- mycobacterium tuberculosis
- gestational age
- drug induced
- hepatitis c virus
- bone marrow
- human immunodeficiency virus
- study protocol
- newly diagnosed
- replacement therapy